GJMPR Volume 7, Number 1: January-June, 2019

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Balanites aegyptiaca Modulates the Lipid Profile and Testicular Histopathology in Streptozotocin-Induced Diabetic Rats through an Antioxidant Mechanism

Isam M Abu Zeid, Saed A Al-Thobaiti, Daklallah A Almalki, Soad S Ali, Abdulrashid Umar

ABSTRACT Background: Hyperlipidemia is a confirmed consequence of diabetes mellitus that follows hyperglycemia. Moreover, diabetes plays a crucial role in testicular malfunction pathogenesis. Objective: The aim of this research is to examine the possible antihyperlipidemic and testicular protective action of Balanites aegyptiaca (B. aegyptiaca ) fruit (flesh, kernel, and their mix) extracts in STZ-induced diabetic rats. Results: Diabetic rats treated with B. aegyptiaca showed significant decrease in the serum TG, LDL, and VLDL levels compared to the nontreated diabetic rats. B. aegyptiaca significantly increased the serum HDL levels compared to the nontreated diabetic rats. Furthermore, B. aegyptiaca extracts protected against STZ-induced diabetic testicular changes. B. aegyptiaca treatment increased level of GSH while decreased MDA level. Conclusion: B. aegyptiaca extract may be utilized as a preventive treatment for hyperlipidemia and testicular disruption linked with diabetes.

[ FULL TEXT PDF 1-7 ] DOI: 10.22587/gjmpr.2019.7.1.1

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